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Those same miRNAs also affect tumor suppressor genes.[ref] While a lot more research is needed here, the impact of miRNA on both tumor suppressors and MTHFR may be part of why folate is both beneficial for preventing cancer and then detrimental during some types of cancer

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Some studies suggest that increasing glutathione can help overcome addictive behaviors, which span from eating disorders to alcohol/drug abuse [57, 58, 59]